Gru and Lucy and their girls—Margo, Edith and Agnes—welcome a new member to the Gru family, Gru Jr., who is intent on tormenting his dad. Gru also faces a new nemesis in Maxime Le Mal and his femme fatale girlfriend Valentina, forcing the family to go on the run.
A fanboy of a supervillain supergroup known as the Vicious 6, Gru hatches a plan to become evil enough to join them, with the backup of his followers, the Minions.
Buster and his new cast now have their sights set on debuting a new show at the Crystal Tower Theater in glamorous Redshore City. But with no connections, he and his singers must sneak into the Crystal Entertainment offices, run by the ruthless wolf mogul Jimmy Crystal, where the gang pitches the ridiculous idea of casting the lion rock legend Clay Calloway in their show. Buster must embark on a quest to find the now-isolated Clay and persuade him to return to the stage.
Joe Gardner is a middle school teacher with a love for jazz music. After a successful gig at the Half Note Club, he suddenly gets into an accident that separates his soul from his body and is transported to the You Seminar, a center in which souls develop and gain passions before being transported to a newborn child. Joe must enlist help from the other souls-in-training, like 22, a soul who has spent eons in the You Seminar, in order to get back to Earth.